Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study

A paper has demonstrated that an oral ciprofloxacin dose of 10 mg/kg three times daily (30 mg/kg/day) may be a suitable alternative antibiotic for the management of sepsis in severely malnourished children.

Ciprofloxacin (10 mg/kg, 12 hourly) was administered either 2 h before or up to 2 h after feeds to
Kenyan children hospitalized with severe malnutrition.Data comprised 202 ciprofloxacin concentration measurements from 52 children aged 8–102 months.

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